To set measurement equipment against a known standard.
Periodic scheduled activity to check and maintain the accuracy of measurements against a known standard.
Cluster of differentiation
A 120 kD glycoprotein antigen expressed on a subset of cells expressing high levels of CD34. Contains a population of repopulating HPC. Defined by the monoclonal antibody AC133. May also be found on neural and endothelial stem cells and other primitive cells such as retina and retinoblastoma and developing epithelium.
A subunit of the T cell receptor complex that includes CD3 gamma, delta and epsilon. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Cross linking of CD3 epsilon with appropriate antibodies can result in T cell activation and proliferation. Binding of antibodies such as OKT3 to the T cell surface can induce such activation whereas CD3 antibodies that do not bind to CD3 epsilon such as T10B9 do not induce T cell activation.
The 115 kD glycoprotein antigen, expressed by 1-2% of normal bone marrow mononuclear cells, that is defined by a specific monoclonal antibody (anti-CD34) using the standardized cluster of differentiation (CD) terminology.
Growth of cells disassociated from the parent tissue by spontaneous migration, migration or enzymatic dispersal.
A propagated culture after the first subculture.
Immune response that involves effector T-lymphocytes and not the production of humoral antibody. Responsible for allograft rejection, delayed hypersensitivity and in defense against viral infection and intracellular protozoan parasites.
The administration of products with the intent of providing effector cells in the treatment of disease or support of other therapy.
Somatic cell-based product (e.g., mobilized hematopoietic progenitor cells, therapeutic cells, cord blood, pancreatic islets) that is procured from a donor and intended for processing and administration.
Code of Federal Regulations
Colony-forming Unit-Granulocyte, Erythroid, Megakaryocytic, Macrophage
Colony-forming Unit-Granulocyte, Macrophage
Current Good Manufacturing Practices
Current Good Tissue Practices
Clinical Laboratory Improvement Amendments